Many bibliographic databases are not well designed for systematic reviews that have geographical focus on LMICs, often about international development, for several reasons.
A well designed RCT guards against systematic and random errors.
The best score for quality of evidence was appointed to a systematic review of multiple well designed RCTs (Scottish guideline, Muir Gray); a systematic review (CCHMC) or at least one properly randomized controlled trial (CPS).
Thus far, homeopathy has failed to demonstrate efficacy in randomized controlled trials (RCTs) and systematic reviews of well designed studies.
In addition, even well designed RCTs can be susceptible to systematic errors leading to biased estimates, particularly when generalising results to "real world" settings.
Recently the debate has focused on whether investigators should include the results of observational studies in systematic reviews, when well designed RCTs are available.
The methodology of the second systematic review [ 1] was well designed and provided reliable conclusions.
The systematic screening of process parameters and well designed settings of parameter levels in optimization phase improved the ITZ encapsulation process.
The systematic review has been conducted by a well designed protocol using robust methodology [ 10, 11] to allow us to identify educationally sound assessments of EBM TTT courses.
Well designed RCTs have strong internal validity as they minimise both random and systematic errors.
