Even the association between HL during CPB and postoperative morbidity/mortality is far from being well defined, the only report being based on a retrospective study [ 5].
Another reason could be the lack of quality of data on adverse events from the original papers, as in most reports adverse events were not well defined and only reported as present or absent.
The longevity of fibrosis in the rodent models is not well defined, with different durations reported between various studies.
In addition, actions, boundaries, and responses have to be well defined if SMS-based reporting tools are to be adopted by national disease control programs.
The clinical phenotype and disease burden in the UK paediatric population are currently not well defined, even though case reports have raised concerns that TA may have the worst long-term prognosis of all the paediatric vasculitides in the United Kingdom [ 5, 8, 9].
Although the approach of ablation of ATs surrounding the region of the aortic coronary cusps and AMJ has been well defined, Das et al reported successful elimination of ATs by catheter ablation at the NCC in 7 of 10 patients with perinodal ATs, although the NCC approach was preferential in 7 patients after ablation at the RAS failed to eliminate the ATs in 3 patients.
To be included, prospective or retrospective studies had to report on well defined cohorts of patients included over a fixed period of time and address mortality as outcome.
A recent inactivation study reports evidence of well defined topographic organization in macaque principal sulcus, as assessed by deficits in performance [6].
Immune correlates of TST have not been well defined and there are conflicting reports on whether PPD induced peripheral blood responses correlate with the TST, making it difficult to interpret the diagnostic potential of the TST [12], [14].
The prevalence of myocarditis since the advent of HAART has not been well defined; however, Pugliese and colleagues reported myocardial disease in 52% of 544 patients treated late in the course of AIDS with NRTIs versus 19% of 498 patients treated with HAART [18].
