Mechanisms through which cognitive impairment affects self-care are not currently well defined but evidence from other patient populations suggests that self-efficacy, or task-specific confidence, mediates the relationship between cognitive functioning and patient behaviors such as self-care.
Although the cellular functions of HIPK1 are not very well defined, available evidence indicates a role in the regulation of apoptosis by interaction with nuclear proteins [ 16, 21].
Although the mechanisms underlying DST-induced allograft tolerance are not well defined, there is evidence to suggest DST induces one or more populations of antigen-specific regulatory cells that suppress allograft rejection.
Until recently, the importance of follow-up sUA testing to guide treatment decisions in patients diagnosed with gout has not been emphasised or well defined by research evidence.
Although the cell signaling underlying AT2 activation is less well defined, there is evidence that AT2 activation results in attenuation of both canonical (Smad-dependent) and noncanonical (MAPK) TGF-β1 signaling cascades, particularly ERK signaling [ 44].
Although the general biochemical scheme/pathway of fungal DHN melanin biosynthesis is well defined based on experimental evidence gleaned from genetic and biochemical studies [ 42], the exact identities, functions and multiplicity of all genes/enzymes involved in melanin biosynthesis, and the possible variation of function among species or strains has yet to be determined.
These staining methods evidenced well defined layers in the entorhinal cortex of control animals where somas had a columnar organization and axon hillocks had parallel directions (Figures 2 C, D and E).
The PXRD patterns of the ITO-coated samples show a well defined (222) peak and to evidence other peaks, the pattern in the region 30° 60° was registered with a higher sensitivity.
A recent inactivation study reports evidence of well defined topographic organization in macaque principal sulcus, as assessed by deficits in performance [6].
The nature of such hospital-based outreach interventions has not been well defined, although there is some evidence that home programs might improve outcomes [ 34, 35].
Although overweight, obesity, and hyperglycemia are clearly associated with increased cardiovascular risk, the effect of their modification on this risk is less well defined by available clinical trial evidence.
