The crucial role of CXCR2 in the host defense against bacteria is well defined in mouse models.
The implications of the decline in T cell and antibody responses are not clear, given that correlates of protection against tuberculosis are not well defined [ 62, 63].
However these rearrangements do significantly complicate attempts to rationally design ligands against well defined but unbound topologies, as seen for the series of napthalene diimides complexes.
Overall, our data suggest that both "generalist" GTs that are able to protect the organism against various stresses and more specialized GTs, required only for protection against well defined stresses, coexist inside the cell.
For example, the antibodies against factor VIII, which formed a narrow repertoire, are known to have been raised against relatively well defined domains of factor VIII that comprise few epitopes [ 20], while antibodies against dsDNA, which formed a broad repertoire, were not raised this way [ 21].
At a later stage when the company has proven out its product, its market, its revenue model and is simply executing against a very well defined plan, the strategic investor can feel confident that what they see is what the entrepreneur is going to do.
While the barriers to such vaccination are not well defined, it is likely that contraindications against live vaccinations during biologic therapy preclude many physicians and patients from using this vaccine (43).
Test kits are usually validated against a set of well defined patients and healthy individuals.
The possible mechanism of action of Bacillus against nematode is not yet well defined.
Immune correlates of protection against H5N1 viruses have not been well defined either in animals or in humans.
In contrast to the NIBSC antiserum, more well defined rings for rHA were achieved using antiserum generated against recombinant antigens.
