Efforts are underway to further analyze these data to identify new treatment targets as well as currently available medications that can be repurposed to treat SSc esophageal dysmotility.
Although generally well validated, currently available biomarkers of exposure for diesel exhaust often show high interindividual variability due to the confounding effects of secondary source exposures.
From the distinct exchange rate of the two substrate water molecules, Wf (fast-exchanging water) and Ws (slow-exchanging water), at each S-state, as well as currently available structural information and the EPR results, Messinger et al. suggested that Wf is the bridging oxygen, O5, which reacts with a terminal oxyl radical formed in the S4 state that is bound to either Mn1 or Mn4.
Exposure data were obtained from the BGS survey of tube wells (Kinniburgh and Smedley 2001), the only nationally representative data on tube-well contamination currently available.
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However, the Canadian climate presents special challenges for constructed wetland treatment systems whose functional reliability is not nearly as well developed as currently available, more conventional, but less sustainable treatment options.
Although the two presented concepts (i.e. fluctuation/oscillation scenario) consistently and equally well explain the currently available experimental data, they imply fundamentally different regulatory principles.
For instance, early developmental events and indirect modulation (e.g. through monoamine regulation) may be more challenging to identify and are not necessarily well characterized in currently available functional gene networks.
The contribution of elevated intraocular pressure (IOP) to glaucoma development and progression is well established, and currently available treatments have focused almost entirely on lowering IOP [ 3].
The feasibility of performing indirect comparisons was assessed according to guidance from the Australian Pharmaceutical Benefits Advisory Board, because these are the only well established guidelines currently available [ 41].
