Seeking clarity about these issues would be an important step in ensuring that policies and practices are consistent with principles of good clinical care, as well as being comparable across settings, both for clinical auditing purposes, and when conducting research and evaluation.
Good metrics are comparable across industries; comparative; readily understandable; and help drive decisions.
The ORPHEA study methods were consistent across the four countries in terms of design, methods, and data collection tools in order for the results to be comparable across countries as well as within them.
IP efficiencies were comparable across the gradient and well reproducible between independent fractionation experiments (Supplementary Figure S2D and E).
Finally, the Qo-LISSY score distribution in terms of standard deviation and range as well as the scale effect size were comparable across Europe and the US, as was the instrument's ability to differentiate between groups based on height.
In a previous presentation of the study, treatment with regorafenib led to significant improvements in OS and PFS over placebo as well as comparable efficacy benefits across all patient subgroups analyzed.
The concentration index is another measure that has the benefit of being comparable across different settings and times, as well as the drawback of being somewhat difficult to interpret.
In addition, patient characteristics as well as outcome on study and after study discontinuation were comparable across the studies.
Demographic characteristics including age, sex, weight, medical history as well as the sepsis site, SAPS II score and mortality were comparable across the three groups.
Overall, rates of serious AEs were comparable across treatment groups in African American subjects as well as in the Caucasian subjects.
