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To realistically receive approval from the Food and Drug Administration FDAA) for ultimate in vivo applications, nanoparticle solutions must be homogenous and well characterized to ensure consistent particle performance [17].
Prior to our study, a handful of proteins were well characterized to be HDAC6 substrates, such as α-tubulin (Hubbert et al., 2002; Zhang et al., 2003), Hsp90 (Kovacs et al., 2005), and peroxiredoxins (Parmigiani et al., 2008).
The 5-HTTLPR polymorphism has been well characterized to affect 5-HTT expression: The S and L alleles in the 5-HTTLPR result in lower and higher levels of 5-HTT expression, respectively [25].
The HT O tBu, composed of various ratios of Mg/Al (i.e., 2, 2.5, and 3) and different contents of tBuO− (Mg/Al 3), and their precursors were prepared and well characterized to draw a correlation between structure and reactivity of the hydrotalcites in WE reactions.
These regulators are well characterized to be modular systems, and include the AraC, MarR and MerR protein families [20].
The role of skeletal muscle L-type Ca2+ channels (Cav1.1) in the pathophysiological mechanism of Duchenne muscular dystrophy has not been well characterized to date.
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Thus these data indicate that, in addition to well characterized responses to body mass, skeletal tissue also responds to the perception of nutritional status by the hypothalamus independently of body weight.
Progressing from the clock network, we then apply the method to less well characterized genes to suggest functional and regulatory roles.
During this period, O2 is consumed in a zero-order process [31], apparently leading to inter-mediates that are not well characterized, prior to the formation of peroxides.
Exercise is a very well characterized mechanism to increase blood lactate levels [12], and exercise has been demonstrated to play a protective role in AD [21].
Three major classes of immunostimulatory CpG-ODNs are well characterized according to their in vitro activities and chemical compositions.
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