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The most well characterized of these are motifs A and B, which regulate the fidelity of replication and the incorporation of nucleotide analogs such as dideoxynucleotides.
In particular, the most well characterized of those, A379V confers only a 7.2% difference in Lp-PLA2 activity between AA and VV homozygotes[16].
It is the least well characterized of the DNA repair pathways, and is generally divided into error-prone and error-free branches, although there is some disagreement as to the number and sub-branches therein [15] [18].
IL-2 is the most well characterized of these, and has been used in clinical trials to enhance CD4 counts in HIV infected individuals [25] [28], however, its direct effect on HIV-specific T cells has not been well characterized.
Lung cancers are the most studied and well characterized of the IAP cancer associations (IARC 2010).
The distribution of mGlu8 receptors in the basal ganglia is the least well characterized of all.
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The possible role of insulin signalling in the anoxic tolerance of Drosophila was evaluated using a series of well characterized mutants of the insulin signalling pathway.
One of the well characterized phenotypes of this mutant is the lack of SA-dependent activation of the PR1 gene [ 18, 21].
These properties were compared with those of well characterized representatives of the two main aquaporin sub-families.
In addition, we also tested the effect of Stattic, a well characterized inhibitor of Stat3 that blocks dimerization of Stat3 through phosphor-Tyr (Schust et al., 2006).
Despite these findings, the transmission cycle of F. tularensis is not well characterized because of the rare occurrence of natural outbreaks involving humans.
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