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Considering the well characterized function of COMT as an enzyme involved in catechol inactivation, it was conceivable that the effect of COMT on migration and adhesion could be related to a dopamine- or catecholic estrogen-mediated mechanism, since these substrates for COMT can be derived from fetal bovine serum or might be produced by B lymphoblasts in culture.
The most well characterized function of ENaC is transport of Na+ across epithelial barriers (Alvarez de la Rosa et al., 2000; Kellenberger and Schild, 2002).
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In contrast to these well characterized functions of MMP-1 in tumor progression, its role in brain metastasis has received less attention.
Cell cycle regulation and involvement in mitotic spindle organization represent well characterized functions of survivin in cancer cells, therefore 24 hours after siRNA transfection in SW1353 cell cultures, cell cycle distribution was analyzed by propidium iodide staining and fluorescence-activated cell sorting.
In addition to its well characterized function in mediating the initiation of DNA replication, ORC also contributes to the formation of silent chromatin [ 7- 9].
αSNAP has a well characterized function in SNARE complex disassembly.
A limited screen of p53 mutations did not identify well characterized loss-of-function mutants, however a larger and more comprehensive profiling with for example whole exome sequencing would be required to be certain of the true rate of p53 mutations in this tumor sub-type.
The present work develops a method to calculate an inverse of an arbitrary SRS using three sets of well characterized basis functions: an impulse function, a sine function/damped sine function, and a modified Morlet wavelet.
VEGFB is most closely related to VEGFA [ 46, 81]; however, the biological function of VEGFB is less well characterized than the function of VEGFA.
Genes located upstream and downstream of pecace are in some instances well characterized but the function of the corresponding proteins could not bring any clues about the role of PECACE, nor any evidence on pecace gene transcription.
Respiratory patterns: As previously described [47], M/T cell activity is well characterized as a function of its temporal pattern along the respiratory cycle.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com