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This model has been well characterised on the FVB/N background strain, a strain that develops severe retinal degeneration.
To obtain quantitative insight into the reaction capacity of aquifer sediments, non-sandy minor subunits should be well characterised on their reaction capacity as well as their spatial occurrence in the geological formations.
In order to identify pathways that are affected by E-cadherin inactivation, we performed a genome-wide expression study on 27 human mammary cell lines, which are well characterised on E-cadherin RNA and protein expression status.
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While the toxicity profile of definitive radiotherapy is well characterised, data on side effects of adjuvant irradiation is relatively sparse.
We identified an initial set of 92 genes from [ 12] associated with a curated subset of ChIP-bound enhancers that have well characterised effects on expression (see Methods).
For example, a gene harbouring a mutation with a well characterised effect on fat percentage, diacylglycerol O-acyltransferase 1 (DGAT1) was within the window for plectin, a gene in the RNASE5 pathway [ 30].
The regulators we have focussed on are all well characterised in at least one fungal species and represent a range of different physiological functions, including 21 regulators involved in development and/or morphology, 19 regulators involved in carbon metabolism, and 13 regulators involved in nitrogen and amino acid metabolism.
However, by focusing on well characterised effects in a defined trait, instead of general inbreeding depression in fitness, we have shown that it is possible to identify major genetic factors and these will likely be amenable to detailed molecular characterisation.
The MDM2 p53 interaction is structurally and biophysically well characterised, whereas equivalent studies on MDM4 are hampered by aggregation of the protein.
The blended polymeric materials were developed from commercially available, inexpensive and well characterised biodegradable polymers, which on their own lacked both the structural requirements of a scaffold material and, critically, the ability to facilitate cell growth.
On well characterised archived isolates for each of the viruses (Table 1), only the intended target virus was amplified by the mRT-qPCR.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com