IL-10 has a well characterised role as an immunosuppressive cytokine and has been implicated in the function of regulatory T cells 47. IL-6 is pleiotropic, but has also been shown to have immunosuppressive effects with DC 48.
While the three nucleolar-association groups display vastly different Gene Ontology biological process signatures and evolutionary characteristics, they collectively represent the most well characterised nucleolar functions.
Furthermore accepted threshold measures of gene stability and pairwise variation are well described with this method [ 11], and the genes we evaluated have well characterised biological functions, and for whom no co-regulation has previously been reported.
They share a well-conserved hydroxylase domain in their C-terminal halves, whereas the N-terminal halves are more variable and have poorly characterised functions among these three isoforms [ 20].
Vascular endothelial growth factor action in tumour angiogenesis is well characterised; nevertheless, it functions as a key element in the promotion of the immune system's evasion by tumours.
In neurons carrying the well characterised loss-of-function mutant alleles chic221 and chic05205, filopodia lengths were reduced to 71 77% relative to wildtype (Fig. 4B, C, E).
The putative roles of poplar genes PtaHB1 and PtaHB7from to distinct well characterised subclades with contrasted functions in crops were examined with respect to over-expression effects upon vascular differentiation and RNA transcript profiles.
Primary Drosophila neurons carrying well characterised ena loss-of-function mutant alleles (enaGC1, ena23) displayed severely reduced filopodia numbers (46 69%; Fig. 1F, I), as was similarly reported for epithelial cells at the leading edge during dorsal closure in Drosophila embryos [21], [22].
VPS34 inhibition itself is well characterised in disrupting lysosomal function, primarily through blocking sorting and trafficking of receptors and hydrolases on route to lysosomes (Raiborg et al, 2013).
Tumour viruses have been well characterised to antagonise the function of the p53 tumour suppressor and more recently several viruses have been shown to target upstream checkpoint kinases as well.
