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The complex nature of the virion structure has been well characterised at high resolution along with the definition of the virus encoded enzymes required for RNA replication; the ordered assembly of the capsid shell as well as the protein and genome sequestration required for it; and the role of host proteins in virus entry and virus release.
Although this pathway is less well characterised, at least two amino acid transporters, encoded by pathetic (path) [31] and slimfast [30] have being suggested to mediate this branch of TORC1 regulation.
As the safety and tolerability profile of DHA and PQP has been well characterised at the doses proposed for the present study, it was considered acceptable to adopt this approach in the present study that would result in more patients receiving DHA/PQP.
The regulation of proinflammatory gene expression in fish has received much attention in recent years, where major cytokines involved in the development of inflammation including TNFα and IL1β have been well characterised at the level of gene expression in a number of different fish models including the carp [22] [25].
The patients included in the ADD study will be extremely well characterised at base line in relation to a number of factors know to relate to TRD as well as influencing HPA axis function.
The patterns of PrPSc deposition in prion diseases are well characterised at immunohistochemical and ultrastructural levels [ 1, 2] and most observations focus on pathological changes in the grey matter.
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Since efficacy studies are logistically challenging, consortiums of investigators that care for well characterised at-risk cohorts (e.g., IVDUs and men who have sex with men) could be established now.
The regulators we have focussed on are all well characterised in at least one fungal species and represent a range of different physiological functions, including 21 regulators involved in development and/or morphology, 19 regulators involved in carbon metabolism, and 13 regulators involved in nitrogen and amino acid metabolism.
These T-PLLs in ATs have been well characterised in the past by several groups including us, and are quite invariably preceded by a T cell clonal expansion identifiable cytogenetically to carry a t(14 14 q11 q32.1) translocation or an inv(14 q11 q32.1) inversion or a t(X 14 q28 q32.1) translocation.
We sequenced the region spanning the well characterised polymorphism at -1607 from the transcription start site in the MMP-1 promoter [ 16- 19] and found that this polymorphism was strongly associated with the bimodal expression observed in the HUVEC dataset.
Maternal nutrient deprivation has been well characterised in this context.
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CEO of Professional Science Editing for Scientists @ prosciediting.com