Therefore, in aquatic ectotherms, the TSR might very well be mediated by temperature effects on oxygen availability and oxygen demand.
Thus, the tolerance effect could very well be mediated by interaction of the TSP-1 C terminus with CD47 [16], [16], or interaction of the type I repeats with CD36 [17].
Thus, any "supportive" effect of IDO-specific T cells on other immune cells may well be mediated in several direct and indirect manners.
Since potential HNF4α binding sites were detected in the conserved module A (as well as in the -295/-265 module), the liver-specific stimulation of HL promoter activity may well be mediated by HNF4α.
Actually, the effect on cell transformation of many environmental factors, which are reported in epidemiological studies to be associated with a certain risk for a given cancer type, might well be mediated by epimutations.
It may well be mediated by nuclear liver x receptor-alpha (LXRa), the expression of which has recently been reported to be positively regulated by TH receptor-beta (TRb) in the mouse.
Since the patterns of JA and JA-Ile concentration were similar to those of the terpene synthase transcript levels, terpene production might well be mediated by a JA-dependent signaling process.
A relation among shift work/sleep disturbances, insulin resistance, and T2D may well be mediated through adiposity or weight gain influenced either by disturbances of the hormone systems or by changed dietary and exercise patterns (24).
Similarly, HSP90 and HSP70 share the heat-shock responsive element (also found in some metallothionein genes, [ 27, 25]), so its co-expression may well be mediated by this particular regulatory network.
Several of the aforementioned studies suggest an association between breast cancer and prostate cancer that could well be mediated through an increased risk of both malignancies in BRCA2 mutation carriers.
A great many growth factors including TGF-β, IGF, PDGF, FGF and the BMPs are known to be stored in the bone matrix and released during bone resorption [ 19] and it would seem likely that the 1,25- OH 2D3-induced apoptosis may well be mediated by the release of one of these.
