Another type of TRP: TRPM8 was detected at high levels in both benign prostate hyperplasia and in prostate carcinoma cells, as well as at low levels in normal (non-carcinoma) prostate epithelial cells.
Steinberger and Roberts [39] argue that saturation point has changed over time, such that current technologies allow much greater well-being at low levels of energy consumption from the period of 1975 to 2005.
Given that cadmium is a well-established nephrotoxicant even at low levels of chronic exposure (Åkesson et al. 2005), underestimation of the potential effects of cadmium on blood pressure and hypertension is a concern.
Since the NRDC filed its FDA petition, Janssen said there have been hundreds more published BPA studies that point to a "wide variety of effects," as well as "evidence of harm at low levels of exposure".
Generally, it is well known that A3R is expressed at low levels in the whole organism [ 41], as well as in the brain [ 1– 6], especially compared to the high expression rates of the A1R and A2AR in the CNS.
Lead exposure, even at low levels, is well known for its harmful effects on children, resulting in lowered IQ.
However, there are limits to the sensitivity of microarrays for detecting genes expressed at low levels as well as additional confounding problems associated with arrays [ 19- 23].
In some rural areas or island countries, the disease transmission intensities as well as the reproduction numbers remain at low levels due to limited human mobility and contacts.
Epidemiological studies indicate an increase in risk for tumours at all sites for high levels of exposure, while few and heterogeneous results are available concerning the effects in humans of long exposures at low levels, as well as at levels that the general population may be exposed to.
Immunohistochemistry revealed that CARNS protein was primarily localized close to the apical membrane of the proximal tubules, as well as in the glomeruli [albeit at low levels (Fig. 1b)].
