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Genes were identified in the Ensembl annotation (Ensembl release 76) of the Tasmanian devil genome where well annotated by Ensembl's automatic annotation.
Considering that diseases have been recently well annotated by human phenotype ontology (i.e., a controlled vocabulary database) and semantic similarity measures can be used to calculate similarities among them.
We used categories curated in GO and KEGG databases and phenotypes annotated in the MGI database and will not have detected signal in functional processes not represented or well annotated by those systems.
Major gene families involved in detoxification of xenobiotic substances, such as cytochrome P450 and GST genes, are not well annotated by automated approaches.
Since this is difficult to measure, we can approximate this number for organisms whose transcripts are well annotated, by assuming that the total number of base pairs of RNA in the cell is proportional to the total number of base pairs of annotated transcripts by some constant c.
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We further considered only cases where the known genes were coding and well annotated, as indicated by a RefSeq accession prefix of "NM_".
That is the case here because of the 252 genes identified, only 126 are sufficiently well annotated for pathway analysis by Ingenuity Pathway Analysis.
Since a few genomes of agriculturally important species (e.g., rice, poplar and grapevine) have been sequenced and even fewer have been well annotated, the data provided by cDNA-AFLP experiments may represent a valuable resource for functional genomics and genetics in non-model plants.
All hypotheses about what happened before or after the latter split may gain additional evidence if this species is included (genes are not very well annotated in Trichoplax, so some prediction by homology may be needed).
The development of new metabolic models is facilitated by using previously inserted, well annotated components that were created during prior reconstruction processes.
However, SwissProt is uniformly well annotated as compared to NR where informative functional annotation can easily be buried by numerous uninformative hits at similar e-values.
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