However, McBride and colleagues used metabotropic glutamate receptor (mGluR) antagonists to ameliorate behavioural deficits in a Drosophila fmr1 mutant; these treatments worked well, whether administrated to embryos or adults (McBride et al., 2005).
As numerous therapeutic agents are not well tolerated when administrated systemically, localized and controlled delivery can help to decrease their toxicity by applying an optimized drug concentration at extended exposure time.
In fact, MLN4924 was well-tolerated when administrated to mice.
Antibacterial therapy was administrated as well as other symptomatic therapy and daily dressings were applied.
Although it has been well established that systemically administrated MSCs specifically migrate into tumor lesions, the role of recruited MSCs in the tumor microenvironment is still not fully elucidated yet.
We will time the length of the interview, as well as the length of finishing interviewers' administrated or patients' administrated questions.
The combinational strategy has also shown efficacy when combining therapeutic antibodies with cytotoxic agents, as well as simultaneously administrating two or more therapeutic antibodies.
The routes were well organized, funded, maintained, and administrated by the Mongols.
In the western United States, livestock often grazing co-exists with recreation, cultural resource management, and biodiversity protection on most federal and state administrated rangelands as well as on many local government open space areas (Resnik et al. 2006).
In a study conducted by Hallerbäck et al. [ 11], the Psychological General Well-Being Index (PGWB) was administrated to 1526 patients with esophagitis (192), gastric ulcers (109), duodenal ulcers (426), duodenitis/gastritis (296), negative endoscopy (401) and other diagnoses (102) before endoscopy.
Seizures occurred in thirteen (54%) during hospitalization, and ten (77%) of those seizures were not well controlled even though antiepileptic drugs were administrated for > 48 hours.
