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Cumulative comorbidity was determined using the Charlson comorbidity index, assigning different weights from 1 to 6 for different disorders, eg, coronary heart disease is weighted 1 and tumor with metastasis 6. 26 We applied the Mini-Mental State Examination, scored from 0 to 30, and the Clock-Drawing Test, scored from 0 to 5. 27, 28 In both tests, low scores indicate cognitive impairment.
Data on Dnase1 mRNA levels and EDS in mesangial matrix (weighted 1 in Figure 5A and B), or in GBM (weighted 2) where combined and sorted by descending Dnase1 mRNA levels.
Categories were weighted 1, 3 and 56, respectively.
In the linear combination, the number of HA-H3.3 nucleosomes at the center is weighted 1 and the number of HA-H3.3 nucleosomes in the two neighborhoods at both ends is weighted 0.5.
These variables were staged into a diagnostic score according to results of the logistic model (table 2): increased root length was weighted 2 and the two remaining variables were weighted 1. Signs were either present (scoring either 1 or 2) or not (scoring 0).
There are three different types of edges in the network that are differently weighted: 1. miRNA targets protein → et 2. TF regulates miRNA → er 3. Protein-protein interaction → ei In the network model, we specify that et = 1, et > er > ei > 0. The weight for er is sampled randomly from a uniform distribution between 0 and 1.
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Each calibration curve was analyzed individually by using least square weighted (1/X 2) linear regression (obtained by best fit method).
Next, data on proteinuria and deposition of EDS in either the mesangial matrix only (weighted 1 in Figure 4B) or also in the GBM (weighted 2 to make a visual distinction from deposits in the mesangial matrix in the figure) were combined for each mouse, and the paired data were sorted by ascending values of proteinuria.
NOT forced origin, weighted (1/concentration) Quad: Polynomial 2. Ord.
forced through origin, weighted (1/concentration) XQOff: Polynomial 2. Ord.
The score encompasses 19 medical conditions weighted 1-6 witotaltal score ranging from 0-37.
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