In contrast to the common ID4 downregulation in several human tumour entities, one study detected increased ID4 expression in rat mammary gland cells in conjunction with increased weight, proliferation and invasiveness of these tumours [ 19].
To increase the power of validation of potential biomarker transcripts, we used biological end points including uterine weight, proliferation and/or apoptosis of epithelial cells, increase in luminal epithelial cell height, and induction of apoptosis inhibitor, thus providing phenotypic anchoring to support transcriptional responses.
After 6 weeks on the LCaHPD rabbits develop parathyroid hyperplasia characterized by increases in PTH secretion, glandular weight and proliferation and by a decrease in CaRmRNA.
D3 markedly increased uterine weight and proliferation of the uterine epithelium in ovariectomized mice, whereas D1 and D2 were inactive.
Besides, concomitant administration of GLP-2 and EGF has additive effects increasing small intestinal weight, cellular proliferation, and morphometric measurements of villus and crypt area [ 36].
The luciferase activity in tumours showed excellent correlation to tumour weight and proliferation, thus validating the model with more traditional tumour evaluation methods.
However, a smart dialogue between the foetus and placenta could bring adaptive responses through regulated epigenetic mechanisms leading to increased weight, cell proliferation, increased vessel density and increased transport capacity.
Unlike estradiol, PME did not increase the uterine weight and proliferation in bilaterally ovariectomized Swiss-Albino mice models and its cardioprotective effects were comparable to that of 17 β -estradiol.
Tumour weights and proliferation indices were ∼29 and ∼152-fold greater, respectively, in the Taxol group in comparison to PTXePC.
GnRH-a suppressed uterine weight, decreased osteoblast proliferation, bone strength, trabecular bone volume and architecture compared to control.
4) Fgf10 overexpression after hyperoxic injury does not increase mortality and side effects (weight loss, mucosal proliferation due to hypercellularity with no impact on apoptosis) are reversible. .
