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The tumor inhibitory rate was calculated using the following formula: Inhibitory rate = [ tumor weight of control group-tumor weight of experiment group)/tumor weight of control group] × 100%.
The rate of tumor inhibition = (average tumor weight of control group – average tumor weight of experiment group)/average tumor weight of control group × 100%.
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However, given the weight of experiments already presented here and our desire to focus this manuscript on the first ever (and hopefully definitive) characterization of the function of the mitotic chromosome periphery compartment, we argue that tests of the hypothesis should occupy future studies and are beyond the scope of this manuscript.
Parameters for weighting of experiments to accommodate for experiment-specific factors such as experimental platform, or a parameter for a probabilistic model may also be used to account for random noise in the data set.
We also provide a quality metric which can be used qualitatively to flag weak or untrusted signals or quantitatively to modulate the weight of each experiment or gene in higher level analyses (clustering or discriminant analysis).
We are open to specific suggestions as to how to decrease weight of particular experiments but do wish to avoid creating additional supplemental figures.
Male Lister Hooded rats (Harlan Olac Ltd ,Bicester, UK) were housed in groups of 4 for Experiments 1 (n = 24; average weight at start of experiment: 408 g) and 2 (n = 20; average weight at start of experiment: 349 g) on a 12 h light/dark cycle.
Twenty-one male Lister Hooded rats (Harlan Olac Ltd ,Bicester, UK; average weight at start of experiment: 342 g) were subjects in this experiment.
Computational formula on growth rate SGR (%/d): SGR = [(W t / W0 1/ t − 1] × 100%, among which SGR is specific growth rate, W0 is green weight of Hypnea when experiment began (unit: g), W t is the green weight at t time (unit: g), and t is spacing interval between two measurement times (unit: d).
The normoxic animals gained weight during the four weeks, while the hypoxic rats had a significant lower body weight after four weeks of experiment.
In contrast, age-matched Hdac6 transgenic mice maintained body weight by the end of experiment day 12 (Fig. 2C).
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