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Methods: Developmental outcome at age 3 years was examined in 21 pairs of discordant (>15% birth weight discordance) very low birth weight (VLBW) premature twins.
In order to analyse epigenetic data from birth weight discordant twins, we introduced a mixed effects model [ 20] with fixed effects of age, sex, birth weight discordance in percentage defined above, random effects for batches (plate and well) and sample location on the array.
Objective: This study was undertaken to evaluate intertriplet birth weight discordance.
To evaluate the usefulness of sonographic prediction of significant birth weight discordance in twin pregnancies.
Birth weight discordance between surviving twins was increased with greater starting number.
To determine an appropriate cutoff value to differentiate physiologic and pathologic birth weight discordance, to determine the prevalence of birth weight discordance ≥25% among twin pregnancies in different sub-populations, and to examine its clinical significance.
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In this regard, biologically more relevant tissues could help with identifying the epigenetic patterns associated with birth-weight discordance.
When plotting the twin pair-discordance in birth weight against the degree of discordance in site-specific methylation at age 4, only a few CpGs were found to interact (one CpG site each at IGF2dmr0 in blood/saliva DNA, one CpG at LINE-1 repeats in saliva DNA), with 26 to 36% of the intra-twin pair divergence at these sites explained by prenatal growth discordance.
Weight misperception is the discordance between an individual's actual weight status and the perception of his/her weight [ 3].
Discordance of birth weight has been observed in twin pairs, though little is known about prenatal and early neonatal discordance of head and brain size, and the role that zygosity and chorionicity play in discordances of early brain development in twins.
Our association analysis revealed no CpG site with genome-wide statistical significance (FDR < 0.05) for either qualitative (larger or smaller) or quantitative discordance in birth weight.
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