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Our results are of relevance for all hypoxia-PET tracers and any tumour site where transport of small-molecular weight agents is challenged.
The reviewed findings provide a proof of principle that targeting of critical repetitive sequences (not necessarily coding regions), which allow for clustering of drug binding motif, can be the paradigm for region specificity of small molecular weight agents.
For example, their susceptibility to digestion with subtilisin [1], their velocity and extent of reactivation from guanidine chloride unfolded monomers [2], and their susceptibility to inactivation by several low molecular weight agents [3].
High molecular weight agents are mainly absorbed through lymph nodes, whereas low molecular weight agents are mainly absorbed through vessels [ 30].
Small molecular weight agents readily leak from the vasculature and distribute within the tissue according to a concentration gradient.
In asthma due to low-molecular weight agents (e.g. isocyanates, anhydrides), an IgE or IgG-mediated response may be involved [ 11].
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Each element (T_{ij}) of this matrix represents the weight agent i places on j's current belief in forming her own next-period belief.
The network of interactions is captured by a non-negative row-stochastic matrix T, such that begin{aligned} sum _{j=1}^n T_{ij} = 1,quad forall i in N. end{aligned} (1 Each element (T_{ij}) of this matrix represents the weight agent i places on j's current opinion while forming her next-period belief.
The absorption rate of IHL-305, a high molecular weight agent, has been shown to be lower than that of CPT-11.
An allergic immune response generally involved if the exposure constitutes of a high-molecular weight agent (e.g. latex, enzymes, animal dander) [ 10].
The use of monoclonal antibodies alone may lead to heterogeneous uptake within the tumour tissue; the use of a second, low molecular weight agent may provide greater penetration into tumour tissue.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com