We plotted mineral particle alignment and degree of mineralisation versus applied stress for the oldest (10 weeks) wild type and Hpr mice in our data set.
After 16 weeks, wild type animals remain able to control their carbohydrate metabolism and they are progressively expanding their adipose tissue.
Male mice, five homozygous wild types and five homozygous mutants, were analyzed using the grip/strength test at 20.6 ± 0.3 weeks (wild type) and 20.7 ± 0.3 weeks (mutant) of age for the first measurement, and measurements were repeated once a week for six weeks.
Estimated 1-year PFS and 2-year OS according to primary tumor genotype were as follows: KIT exon 9 mutations - 68%/73% (median 65.5/151.5 weeks), wild type - 57%/70% (median 50.5/121 weeks), KIT exon 11 mutations - 34%/34% (median 36.8/65.5 weeks) and PDGFRA mutations - 15%/25% (median 9/40 weeks).
At the age of 9 weeks wild-type and C3.Dll1tm1Gos/+ mice were analyzed for 26 dysmorphology parameters (see Materials and Methods).
Under the dietary conditions, there was no significant difference in the amounts of food intake between the two genotype mice fed HF diets for 16 weeks (wild-type, 2.77±0.18 g/day; IVA-PLA2-knockout, 2.90±0.27 g/day, n = 5), or between those fed normal diets for 16 weeks (wild-type, 3.68±0.18 g/day; IVA-PLA2-knockout, 3.89±0.10 g/day, n = 7).
After 28 weeks, wild-type male and all MT-null mice exposed to MeHg weighed significantly less than control mice, which may signal an emerging toxic effect.
At the age of 17 to 19-weeks wild-type and heterozygous Dll1tm1Gos mutants entered the metabolic screen in the GMC, and were analyzed as described previously [79] [81].
With the same NIR (OsteoSense 750) probe, our results showed that in normal mice, paw signals were significantly lower in older mice (for example, P = 0.029, comparing 8-week and 12-week wild-type mice).
Numbers of males used per time point were: 13 weeks, 8 wild type and 10 SOD1 G93and; 17 and 17 weeks, 12 wild type and SOD1 G93Adl; 19 weeks, 8 wild type and 10 SOD1 G93Adl; 23, 23 and 25 weeks, 12 wild type and 10 SOD1 G93Adl; 27 weeks, 8 wild type and 10 SOD1 G93Adl; 29 weeks, 12 wild type and 5 SOD1 G93Adl; 31 weeks, 12 wild type and 10 SOD1 G93Adl; 33 weeks: 8 wild type and 10 SOD10G93Adl.
Cohort sizes for females per time point were: 13 weeks, 5 wild type and 10 SOD1 G93and; 17 and 17 weeks, 12 wild type and 10 SOD1 G93Adl; 19 weeks, 7 wild type and 5 SOD1 G93Adl; 23, 25, 27, 29, 29, 31 and 33 weeks, 12 wild type and 10 SOD10G93Adl.
