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After 2 weeks, the decrease of the biosensor response was lower than 70% of its original response.
After 12 weeks, the decrease in mean A1C had reached a maximum level and may have further decreased if the duration of treatment had been extended.
After treatment of 8 weeks, the decrease of LDL-C in the rosuvastatin group was significantly greater than that of the simvastatin group (43.2% vs 35.3%, P<0.05).
For specimens kept in PBS for 25 weeks, the decrease in volume was 8.7 ± 1.5%, and for those kept in serum solution the decrease was 5.4 ± 2.5% (both significant in comparison to time point 0, p ≤ 0.01).
After 30 weeks of treatment with pegaptanib (Wroblewski and colleagues), 38 44 differences in decrease of CRT versus sham did not reach significance, but at 52 weeks, the decrease in CRT was significantly greater in both the 0.3 mg and the 1 mg pegaptanib groups compared with sham.
Despite the fact that the risk of venous thromboembolism was high in the later period after discharge (five to 10 weeks), the decrease in the risk from around 1800 (during admission) to 387 per 100 000 person years shows some longer term effect of admission on the incidence of venous thromboembolism.
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Additionally, about one third of the 88 people who did not achieve a PASI 75 score at 12 weeks while taking 50 mg biw did at 24 weeks despite the decrease in dose.
A decrease in mTCNS (improvement) was observed in all groups as early as 12 weeks, and the decrease in mTCNS persisted (or decreased more) during the study in all groups to week 52 without significant differences between groups.
Reddy, et al showed that treatment with ciglitazone (an agonist of PPARγ) for 8 weeks ameliorated the decrease in elastin contents [ 16].
By week 4, the decrease became significant and more pronounced (week 4: 6.8±0.9 ml/kg/min, P = 0.016).
After 17 weeks, the average decrease of MCwb was 7percentt.
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