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However, the duration of protein restriction was shorter in our study, 10 weeks instead of 18 weeks previously reported [ 3, 21].
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The iMSUD mice maintained on a normal diet survived a maximum of 8 weeks (Fig. 3A) with most of these mice dying between 5 and 8 weeks as previously reported (Homanics et al., 2006).
Senescence in GPC-RNAi plants was delayed by approximately three weeks, as previously reported [ 3].
Taps and ice machine water were sampled every other week, as previously reported (11 ).
Findings through week 24 were previously reported; those through week 104 are presented herein.
Safety results through week 24 1 and week 104 2 were previously reported.
Conversely, HBD-2 was not detectable in developing skin from 10 24 weeks EGA, while HBD-3 was focally expressed in the stratum corneum in one donor at 22 weeks EGA, confirming previously reported results by Kim et al. [ 12].
Mice were fed normal mouse chow supplemented with or without 1.8 g/L D.L-Hcy (Sigma Chemical Co., St . Louis MO) in drinking water (n = 6 for each) for 2 weeks, as we previously reported (Dai et al., 2006) with some modifications.
The primary endpoint at 24 weeks has been previously reported.
The median survival for the population as a whole was 112 weeks, comparable to previously reported survival data.
Five trials [ 45- 49] reported at times longer than 12 weeks, (26 to 78 weeks); two of these trials had previously reported three week results in separate papers included in the 13 papers of less than six week results.
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