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After four weeks of dosing both values from the SMT C1100-dosed mdx were equivalent to those observed in sedentary mdx and wild type mice.
Chronic treatment with one compound from the series, 3k, showed for the first time that blood glucose and glycated hemoglobin (HbA1c) levels could be significantly reduced in Zucker Diabetic Fatty (ZDF) rats over several weeks of dosing.
Glucose-stimulated insulin secretion, β-cell mass, islet size, body composition, serum metabolic profiles, lipogenesis, lipolysis, adipose hypertrophy and lipid deposition in the liver and muscle were also measured after 12 weeks of dosing.
A partial restoration of the resistance to fatigue was observed in SMT C1100-dosed mice, with an increase in distance travelled of around 50% compared to vehicle only after 5 weeks of dosing.
Fed Insulin levels were measured from plasma after 4 weeks of dosing with SRT501 or vehicle and after 6 weeks of dosing with SRT1720 or vehicle.
After 18 weeks of dosing this animal underwent a final MRI and was euthanized.
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Proteasome inhibition was maintained for ⩾48 h following the first dose of carfilzomib in each week of dosing.
Trough concentration data suggested that steady-state conditions were reached in the third week of dosing with either regimen.
The effects of ospemifene on vaginal epithelial height were maintained up to 2 weeks after cessation of dosing.
The 9-week, double-blind, evaluation period comprised 4 weeks of dose optimization (visits 1 4) and 5 weeks of dose maintenance (visits 4 9), followed by a 1-week washout period and safety follow-up (visit 10).
In a double-blind, placebo-controlled, multicenter trial, 125 patients (98% women) with fibromyalgia were randomized to receive placebo or milnacipran monotherapy for 4 weeks of dose escalation to the maximally tolerated dose followed by 8 weeks of stable dose (25 to 200 mg/day) [ 65].
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