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The effects of nimodipine were significant in the hippocampal CA1 area after 4 weeks of administration.
Liu et al., furthermore, showed that 4 weeks of administration of sodium orthovanadate in drinking water significantly improved the outcome in rats with streptozotocin-induced diabetes after cerebral ischemia and reperfusion in terms of neurobehavioral function [28].
Moreover, no signs of toxic side effects analyzed by blood parameter changes were observed after 3 weeks of administration although a high dose (200 mg/kg) of GEM-ANPs were used.
It has been shown that meloxicam does not affect orthodontic tooth movement after 2 weeks of administration via drinking water in Wistar rats and seems to be safer than other selective NSAIDs [39].
This research was designed to examine the effect of three weeks of administration of corticosterone (20 mg/kg) on endocannabinoid content and cannabinoid CB1 receptor binding in the amygdala.
With respect to those observed for untreated healthy mice, both the low- and high-dose groups of 110-nm GEM-ANPs and 406-nm GEM-ANPs elicit no significant variation of rat blood parameters after 3 weeks of administration (p > 0.05).
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In the chronic experiment, 8 animals treated with BTZ died within the first 4 weeks of administrations, while treatment was well tolerated by the surviving animals.
after 1 week of administration.
Thresholds in the IS group held steady at 2 g after 1 week of administration.
We found that i/v and i/p administration of Bio-ZnONPs in three different doses did not cause mortality and body weight was slightly reduced up to second week of administration compared with the vehicle control group.
It can be seen that i/v and i/p administration of Bio-ZnONPs in the three different doses (NOAEC, IC50 and TLC) body weight was slightly reduced up to second week of administration compared with the control group.
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