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Patients will be stabilized on a single-pill, triple-antihypertensive-drug combination for 4 weeks before randomization to treatment or sham.
The averages of the measurements at visit 1 (16 weeks before randomization) and visit 3 (6 weeks before randomization) were used as baseline values.
Patients were drug-naïve, defined as an absence of any oral or injectable antihyperglycemic therapies for ≥12 weeks before randomization.
A bone scan or skeletal survey using radiography, CT scanning, or MRI was required within 6 weeks before randomization.
Patients administering GL at any time other than prebreakfast were converted to a prebreakfast basal injection 2 weeks before randomization.
The patients were examined 13, 12, 8, 4, and 2 weeks before randomization, at randomization, and 1, 4, 8, 11, 12, 16, and 24 weeks after randomization.
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All patients are asked to record angina diaries for one week before randomization (baseline phase).
A week before randomization, fasting (≥12 h) blood lipid profiles were obtained to determine eligibility.
Participants will be asked to fill in angina diaries from one week before randomization to 16 weeks after randomization.
Meanwhile we must confirm all the participants did not use any gastrointestinal drugs at least 1 week before randomization and never joined any other trial in progress.
Homoarginine was measured in blood samples taken at baseline during study Visit 3 (1 week before randomization)., using a reverse-phase high-performance liquid chromatography method.
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