→, followed by; DFS, disease-free survival; HR, hazard ratio; NS, not significant; OS, overall survival; A, doxorubicin; C, cyclophosphamide; E, epirubicin; F, 5-fluorouracil; P, paclitaxel; w, weekly; RFS, recurrence free survival.
Our patient was subsequently treated with weekly, single-dose chloroquine without recurrence of symptoms.
A trial comparing 6 with 9 months thrice weekly ATT demonstrated lower bacteriological recurrence with 9 months treatment, but found no other benefits [ 12].
By daily analysis, in 1999 and 2006 a total of 194 cluster-signals were detected (compared to 75 signals by weekly analysis with a ≥1 year recurrence level, both with non-restrictive parameter settings).
A more recent large case-control study from Hong Kong found intermittent (three times weekly) treatment to be significantly associated with recurrence when compared with daily treatment [28].
Daily analyses in 1999 and 2006 detected fewer clusters than weekly analyses because the threshold level for recurrence intervals (≥1 year) is more strict (see Appendix S2).
Between Feb 1st 1999 and Sept 30th 2006, a total of 35 LRI-clusters with 221 cluster-signals were detected by weekly analysis (Table 1, non-restrictive parameter settings, recurrence interval ≥1 year).
If subjects were cured, recurrence was assessed by means of weekly phone calls during 4 weeks of follow-up.
Margaret Oliphant expressed anxiety about "the violent stimulant of weekly publication with its necessity for frequent and rapid recurrence of piquant incident and startling situation".
She was then started on an immunomodulatory treatment and coinciding with the up-titration of interferon beta-1a, she experienced recurrence of painful trigeminal neuropathy as well as weekly migraine attacks.
