Fifteen partial responses were observed after eight weekly cycles and two other patients with initial stable disease showed partial response after 14 cycles.
In all, 18 patients achieved partial response after eight weekly cycles and two additional patients with initial stable disease showed partial response after 14 cycles.
Tumour measurements for response assessment were performed after eight weekly cycles; patients with responsive or stable disease received six additional weekly cycles and they underwent a second measurement at the end of the treatment program.
Patients with responsive or stable disease received six additional weekly cycles and they underwent a second measurement at the end of the treatment program.
Her pre-existing neuropathy significantly worsened (grade 2) after 7 weekly cycles, and the paclitaxel dose was reduced to 20 mg/m.
However her pre-existing neuropathy significantly worsened (grade 2) after 5 weekly cycles, and the paclitaxel dose was reduced to 20 mg/m20
She was commenced on weekly carboplatin AUC 3 and paclitaxel 75 mg/m, however her pre-existing grade 2 neuropathy significantly worsened after 5 weekly cycles, and the paclitaxel dose was reduced to 20 mg/m.
All models were adjusted for season using sine and cosine functions of date to capture annual cycles [i.e., cos((date/365) × 2π) and sin((date/365) × 2π)], day of week (for weekly cycles), and date (to control for time trends over the 4-year course of the study).
