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To reduce the exposure to tamoxifen, we considered the putative advantages of weekly administration.
GH and IGF-1 kinetics showed a dose-proportional increase following a single SC administration of TransCon GH and indicated that the prodrug is suitable for weekly administration.
To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer.
Weekly administration of ch5D12 at two dose levels for 4 weeks was shown to be safe and without any side effects in all monkeys.
Drugs were dispensed in patient-wise boxes each containing blister packs for daily and weekly administration in IP and CP respectively.
Area under the plasma concentration-time profile and maximal plasma concentrations increased over time, suggesting accumulation of ELN 457946 in the plasma with repeated weekly administration.
Similar(8)
Gemcitabine's radiosensitizing properties can theoretically be exploited by twice-weekly administration.
Conclusion: Transdermal estradiol and a twice-weekly administration of the vaginal progesterone gel Crinone constitutes a new, viable hormone replacement therapy regimen.
In addition, the tolerability was better than with a traditional three-weekly administration [ 14, 16].
Pharmacokinetics and pharmacodynamics support once-weekly administration in patients with GHD.
Pharmacokinetic modelling suggest that a 3-weekly administration may be feasible.
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