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After chemotherapy failure (two lines), the patient received trastuzumab with vinorelbine weekly, achieving complete response after 5 months.
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At 12 weeks, 49% of patients who received etanercept 50 mg twice weekly achieved PASI-75 [ 25].
Our data indicate that four of five patients treated with 10 and 20 mg taspoglutide once weekly achieved the treatment target A1C <7% recommended by the American Diabetes Association (17).
In vivo study demonstrated that self-assembled siRNAs I and II/ dextran-spermine and treatment twice weekly achieved better inhibition of CXCR4 expression than naked siRNAs I and II in vivo.
Available data suggest that improvements are maintained for 48 weeks, as 60% of patients receiving 50 mg twice weekly achieved PASI-75 (S.K. Tyring et al., unpublished data presented at the summer meeting of the American Academy of Dermatology, 2005).
This combination greatly reduces the cost of treatment compared with etanercept 25 mg twice weekly while achieving similar efficacy.
Basal insulin was titrated at the investigator's direction weekly or twice weekly to achieve a fasting plasma glucose (FPG) concentration of ≥70 <100 mg/dl, as in the Treat-To-Target Study (1).
Weekly paclitaxel proved a dose-dense alternative to the 3-weekly regimen, achieving at least similar activity in breast and lung cancer, and showing some advantages in terms of feasibility and decreased toxicity.
During the same period evidence emerged that weekly (rather than 3-weekly) paclitaxel achieved high antitumor activity thanks to a considerably increased dose intensity and/or densitiy, yet with no apparent increase in overall toxicity [ 9, 10].
During the first 8 weeks of the study, insulin dose was adjusted at least weekly to achieve an optimized dose for each patient.
In this analysis, a significantly higher proportion of etanercept-treated patients (33 and 49% treated with 25 mg and 50 mg twice weekly, respectively) achieved the primary endpoint of ≥75% improvement in PASI at 12 weeks compared with placebo (P<0.0001).
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