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At 12 weeks, 49% of patients who received etanercept 50 mg twice weekly achieved PASI-75 [ 25].
Our data indicate that four of five patients treated with 10 and 20 mg taspoglutide once weekly achieved the treatment target A1C <7% recommended by the American Diabetes Association (17).
Available data suggest that improvements are maintained for 48 weeks, as 60% of patients receiving 50 mg twice weekly achieved PASI-75 (S.K. Tyring et al., unpublished data presented at the summer meeting of the American Academy of Dermatology, 2005).
In vivo study demonstrated that self-assembled siRNAs I and II/ dextran-spermine and treatment twice weekly achieved better inhibition of CXCR4 expression than naked siRNAs I and II in vivo.
Similar(56)
After chemotherapy failure (two lines), the patient received trastuzumab with vinorelbine weekly, achieving complete response after 5 months.
During the same period evidence emerged that weekly (rather than 3-weekly) paclitaxel achieved high antitumor activity thanks to a considerably increased dose intensity and/or densitiy, yet with no apparent increase in overall toxicity [ 9, 10].
In this analysis, a significantly higher proportion of etanercept-treated patients (33 and 49% treated with 25 mg and 50 mg twice weekly, respectively) achieved the primary endpoint of ≥75% improvement in PASI at 12 weeks compared with placebo (P<0.0001).
At 12 weeks, 32 and 46% of all patients randomized to receive etanercept 25 or 50 mg twice weekly, respectively, achieved PASI-75 (vs. 3% for placebo, P<0.0001 both comparisons).
Basal insulin was titrated at the investigator's direction weekly or twice weekly to achieve a fasting plasma glucose (FPG) concentration of ≥70 <100 mg/dl, as in the Treat-To-Target Study (1).
Also a significant proportion of the patients receiving once-weekly exenatide achieved target HbA1c levels of 7.0% or less (77% vs 61% of evaluable patients, P=0.0039).
This combination greatly reduces the cost of treatment compared with etanercept 25 mg twice weekly while achieving similar efficacy.
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