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after 1 week of administration.
Thresholds in the IS group held steady at 2 g after 1 week of administration.
We found that i/v and i/p administration of Bio-ZnONPs in three different doses did not cause mortality and body weight was slightly reduced up to second week of administration compared with the vehicle control group.
It can be seen that i/v and i/p administration of Bio-ZnONPs in the three different doses (NOAEC, IC50 and TLC) body weight was slightly reduced up to second week of administration compared with the control group.
Beyond this antidepressant efficacy, agomelatine demonstrates sleep electroencephalographic changes consistent with desirable sleep architecture improvements, as well as improved subjective sleep quality within the first week of administration accompanied by an improvement in daytime alertness.
A significant decrease in TT4 was observed as soon as 24 h after ASA administration, whereas the decrease in TT3 was less pronounced and differed significantly from the placebo only after 1 week of administration.
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The effects of nimodipine were significant in the hippocampal CA1 area after 4 weeks of administration.
This research was designed to examine the effect of three weeks of administration of corticosterone (20 mg/kg) on endocannabinoid content and cannabinoid CB1 receptor binding in the amygdala.
Liu et al., furthermore, showed that 4 weeks of administration of sodium orthovanadate in drinking water significantly improved the outcome in rats with streptozotocin-induced diabetes after cerebral ischemia and reperfusion in terms of neurobehavioral function [28].
Moreover, no signs of toxic side effects analyzed by blood parameter changes were observed after 3 weeks of administration although a high dose (200 mg/kg) of GEM-ANPs were used.
It has been shown that meloxicam does not affect orthodontic tooth movement after 2 weeks of administration via drinking water in Wistar rats and seems to be safer than other selective NSAIDs [39].
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