The KEGG database provides various tools and a wealth of pathway-related data that are curated with controlled identifiers and external references.
Just as AlzGene for risk-gene reference database, AlzPathway serves as a pathway "reference" integrating wealth of pathway information published before.
There is now a wealth of pathway and protein interaction data in the public domain, collected and curated at great expense.
Efforts to create centralized repositories of pathways such as Kyoto encyclopedia of genes and genomes (KEGG) [ 3] or MetaCyc [ 4] are struggling with different data models to make pathways homogeneous in terms of representation and coding (see www.pathguide.org for a survey of the wealth of pathway repositories so far available).
BNICE generated a reaction network involving a wealth of novel pathways describing the biodegradation of 1,2,4-TCB to form compounds with known metabolism.
However, given the wealth of novel pathways obtained using these prediction methods, it is necessary to evaluate their relative feasibility, particularly within the context of the cellular environment.
In many ways, the diversity of fungal primary metabolism (a wealth of catabolic pathways, capability to biosynthesize all important vitamins and cofactors) is what makes the primary metabolism of filamentous fungi fascinating and worthy of further study.
Transport and metabolism associated gene products support the wealth of secondary pathways found in moss (e.g., [ 14, 15, 19- 22]), whereas the signal transduction genes also separate the moss from seed plants in this regard.
Given the wealth of novel biodegradation pathways obtained using computational prediction methods, it is necessary to evaluate their relative feasibility.
Despite the wealth of information found for pathway construction mainly from pathway databases, conflicting reports in pathway connectivity makes the construction of the generic topology a non-trivial task with significant manual curation and with no guaranteed for the "right" generic topology.
