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For example, injury to the cord at mid-thoracic levels spares the arms, which are innervated by fibres originating from higher segments, but it causes characteristic signs (abnormal posture, spastic tone, weakness, increased deep reflexes, and abnormal plantar reflexes) of damage to motor neurons originating below that level as well as the loss of bladder and bowel control.
In addition, there are rather acute effects of treatment that can severely affect a child's quality of life, and among these can be treatment-induced loss of hearing, fatigue and weakness, increased susceptibility to infection, and growth retardation.
Increased thigmotaxis exhibited by the Mbnl1−/− mice could be due to muscle weakness, increased anxiety or decreased motivation to explore.
Her weakness increased rapidly.
Leg weakness increased and contributed to the loss of ambulation.
This may be attributed to muscle wasting and weakness, increased muscular fatigability, impaired psychosocial and functional capacity that has been associated with HIV infection [ 7].
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And currency weakness increases the real value of trillions of dollars of debt built up in the last decade.
Quadriceps muscle weakness increases the risk of incident knee pain [ 56] and is associated with increased pain and reduced function in individuals with knee osteoarthritis [ 57].
Moreover, the present work is the first to show that administration of a selective superoxide scavenger, PEG-SOD, completely reversed hyperglycemia-induced diaphragm weakness, increasing force generation in response to the entire range of physiologically relevant stimulation frequencies.
Those political weaknesses increased as China's leaders traveled repeatedly to European capitals and lobbied aggressively and successfully to divide Europe on the issue.
The development of 90CE analogues which eliminate or diminish the phosphate catalyzed decomposition route would be expected to remove this weakness, increase potency, and remove potential toxicities from the thiophilic electrophiles which likely do not significantly contribute to the anticancer activity.
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