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The weakly transported heterocyclic compounds stimulate relatively low levels of efflux with isonipecotic acid (Isonip) being more effective than l-pipecolic acid (l-Pip).
The weakly transported nature of l-pipecolic acid via PAT2 demonstrates that it will have limited utility as a tool to provide unequivocal evidence for PAT2 function in native tissues.
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Thus, in the weakly nonlinear transport regime we find that the equilibrium third current cumulant, C αβγ ( 0 ), is related to the second-order non-linear conductance, Gα,β γ, and the noise susceptibilities, Sα β,γ, by means of a fluctuation relation, C αβγ ( 0 ) = k B T S αβ, γ + S αγ, β + S βγ, α − ( k B T ) 2 G α, βγ + G β, αγ + G γ, αβ.
Uncharged or weakly basic molecules are most efficiently transported by P-gp, but acidic compounds can also be transported.
Sampling the subsequent day at NC08, near the Astoria-Megler Bridge, revealed that low DO water was transported over 14 km upstream, where weakly stressful conditions at the bottom persisted for 3.9 h (Figure 9B, Table 3).
Some of the microtubule velocity measurements were conducted using a different set of microtubules, namely dimly rhodamine-labeled, weakly biotinylated microtubules for surface immobilization via anti-biotin antibodies and brightly rhodamine-labeled microtubules as transported microtubules.
Weakly indurated, largely deforested, and subject to heavy rain and intense erosion, the Siwaliks provide much of the sediment transported onto the plain.
Be transported.
It is assumed that transport is weakly sensitive to mass transfer and mass transfer direction.
This is because, under the conditions we tested, Rnf only weakly couples electron transport with sodium ion translocation, and ATP synthesis is primarily dependent on proton pumping by Fpo and proton translocation by HdrED (16).
However, contrary to some hydroxylated metabolites of other commonly measured environmental chemicals, such as PCBs and PBDEs, BPA binds only weakly to the transport proteins transthyretin and thyroxine-binding globulin (Marchesini et al. 2008).
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