Exact(5)
In our survey, this gene class produced the largest fraction of weakly characterized genes leaving ample opportunity for further investigations.
The GCI scoring system could serve as an important tool for focusing efforts and resources on the study of weakly characterized genes.
However, analyzing GPCRs not targeted by small molecule drugs revealed that the majority had remained weakly characterized with GCI scores for over 60% of genes ranging from 1.5 to 5.4 highlighting opportunity for further study and development of new targets within this highly relevant gene family.
For instance, about 380 yeast proteins are only weakly characterized for cellular component and for more than a quarter of them we predict about 200 functions.
Especially due to the combination of different sources of evidence for functional similarity between proteins, our method is able to predict many functions even for uncharacterized or only weakly characterized proteins.
Similar(55)
Together, these geomorphic indices suggest an area of weakly active tectonism characterized by dip-slip normal fault movement.
It was inferred that in wide pores corresponding to size exclusion chromatography the partitioning proceeds by the coil orientation, and, additionally, that the critical chromatography operates in the regime of weakly adsorbed chains characterized by a diffuse adsorption layer.
Moreover, most of the Vf and Smf values obtained for the Ban Mai, Ban Don Fai, and Sop Prap segments are low (0.44 2.75 for Vf and 1.11 1.82 for Smf; Tables 1 and 2), which may indicate an area of weakly active tectonism characterized by normal dip-slip fault movement.
While most egg chambers from Df 2L dLRCH females appeared normal, we observed a weakly penetrant phenotype characterized by an abnormal number of germ cells (Figure S5).
ABCC13, RBM11 and NRIP1, three euchromatic genes that were either silent or very weakly expressed, were characterized by very low levels of acetylation and were slightly enriched in H3K9Me3.
Proteins that are only weakly and incompletely characterized or not annotated at all are candidates for our prediction approach.
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