Similarly, in obese diabetic (ob/ob) mice, GIP, GLP-1, and (Abu8 GLP-1 displayed substantial glucose-lowering and insulin-releasing activities, whereas (Abu2 GIP was only weakly active.
The only analog to show any tubulin polymerization activity was 14d, but this was only very weakly active (IC50 90 μM) compared with paclitaxel's 0.5 μM response in the same assay.
Alternatively, transcription of differentiation-specific genes might be attenuated, but still weakly active and rapidly switched to a more active state upon activation of respective signaling cascades, initiating and accompanying the transition into another differentiation state.
The crude extracts of B. ferruginea and A. conyzoides were weakly active against MRSA strains with ethanol extract of both plants exerting stronger antibacterial activity than water extracts.
This suggests the presence of weakly active and/or antagonizing components whose interactions with the active constituents could mitigate paired activity and/or overall antimalarial activity of Nefang.
Removal of the acetic acid moiety led to inactive or weakly active target compounds.
However, it is negative or only weakly active in standard in vitro genotoxicity assays.
Together, these geomorphic indices suggest an area of weakly active tectonism characterized by dip-slip normal fault movement.
Ethyl acetate was weakly active in [3] at the ab5B ORN but inactive in the original data.
The 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyses the reduction of the weakly active estrone (E1) into the most potent estrogen, 17β-estradiol (E2).
On the other hand, red beets and spinach strongly inhibited the genotoxicity of N-OH-PhIP, rooibos tea was weakly active while all other items were inactive.
