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Firstly, the fitness uniform selection strategy (FUSS) with a weak selection pressure is incorporated into the standard PSO.
A weaker selection pressure by natural enemies could explain why these particular traits evolved different levels of plasticity.
Moreover, weak selection pressure apparently resulted in the accumulation of mutational changes preventing identification of ancient orthologues.
This suggests that constitutively spliced exons are subject to weaker selection pressure than alternatively spliced ones at the RNA level.
This might have resulted in a weaker selection pressure on individual positions of the PAM than previously thought.
This implies that gene transcription regulation is probably subject to weak selection pressure in Buchnera conserving operons composed of genes with unrelated functions.
Indeed, widespread random horizontal gene transfers under weak selection pressure could only be deleterious, in the end, for the gene pool and its prokaryote hosts.
But how such parallel evolutionary dynamics from conserved genes can lead to the great diversity of known eukaryotes under weak selection pressure?
The HEG domain is therefore still subject to weak selection pressure, even if it is inactive (for example stop codons and frame-shifts will be selected against).
It may be that mechanism variants in late onset disease are under too weak selection pressure for the sequence profile based impact assignment methods to be fully effective.
The low cost required to prevent resistance against late-acting insecticides is because evolutionary pressure on old mosquitoes is low: as there is only weak selection pressure to evolve resistance, a low cost can block evolution.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com