The study was therefore adequately powered to detect weak predisposition to type 1 diabetes conferred by IGF1.
Previous studies looking at the effect of p21 gene deletion have shown that p21 knockout mice have a weak predisposition to tumourigenesis, with an average onset of tumour development of 16 months, with the majority of tumours consisting of sarcomas, lymphomas and tumours of vascular and endothelial origins(Martin-Caballero et al, 2001).
Taken together, current evidence suggests that COMT variants may provide a weak predisposition to a variety of psychiatric conditions via alteration of dopamine levels in the prefrontal cortex (supported by the association of the same haplotype with both, schizophrenia and bipolar disorder) [ 33].
Our results support the view that COMT variation provides a weak general predisposition to neuropsychiatric disease including psychotic and affective disorders.
It is possible that we have not managed to elucidate any relationship due to the young age of our subjects or the sample size being too small to demonstrate a weak effect of genetic predisposition.
Family, twin, and adoption studies strongly indicate that genetics contribute to the etiology of SZ, probably by transmission of multiple susceptibility genes each exerting weak-to-moderate effects on predisposition [ 2, 3].
An alternative explanation is that mt-N interactions predispose chromosomes depauperate of mt-N genes to become sex chromosomes, although this predisposition might be rather weak and highly dependent upon the location of genes involved in sex determination.
The predictive value of predisposition, infection, and response was weaker than that of organ dysfunction.
Despite the above evidences, we have to take into account that the predisposition to other rearrangements is weak given the low incidence of these diseases and the relatively high frequency of some inversions.
The predictive ability of predisposition, infection, and response components is weaker than that of organ dysfunction.
In addition, studies considering the association between genetic predisposition and implant failure have a weak point: the lack of data reporting the periodontal status of the patients.
