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As previously reported, 46 telangiectasia may be a weaker marker of skin ageing in women due to the protective effect of oestrogens on skin microvasculature.
MMP-9 may be a weaker marker of CHD risk in healthy sub-groups because MMP-9 may be more important in de-stabilizing established plaques rather than having a directly atherogenic effect.
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The authors concluded that the gene signature was possibly a combination of weaker markers making its predictive power dependent on the clustering method used in different data sets [135].
A weak marker would fail to reject most of the test trees, not only the concatenation tree.
In summary, the limited available evidence suggests that NGAL is a weak marker of risk for renal function decline but might be a predictor of cardiac event in the setting of HF in patients with and without renal disease.
The latter is consistent with previous work showing that assessment of disease alone is a weak marker of health status in older individuals, even when indicators of disease severity are considered [ 62].
Although, as in the current study, assessment of VD using a pan-endothelial cell antigen like CD31 or CD34 may be a weak marker to predict the likelihood to respond to anti-VEGF therapy, it is stressed that the usage of multi-tissue arrays (MTAs) for the vessel counting (like the method applied in the study by Jubb et al) should not be considered as equivalent to whole tissue sample evaluation.
Moreover, we have shown that, in our case, this correction mainly made it possible to eliminate a certain number of disequilibrium values between unlinked or very weak markers.
Empirical analyses in both non-clinical and clinical samples, have shown that conventionally regarded core symptoms of depression, such as sleep disturbance, changes in appetite, weight change, and loss of libido, are weak markers for the syndrome of depression [ 21].
It must also be stressed that the approximation becomes weaker if markers are less variable (lower theta values).
TasP provides an additional compelling argument for improving access to viral load monitoring as CD4 is a weak surrogate marker of viral suppression.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com