The production for processing exports therefore requires imports and thus has a much weaker linkage with other domestic sectors and consequently a much lower valued added than the normal trade.
Thus, the QTLs detected in the intercross lines are mapped at a timepoint when only half of the degeneration has occurred, which may reduce power to detect the relatively weaker linkage to Vra2.
While this SNP is not a strong proxy for a functional variant, there are multiple functional variants in weaker linkage disequilibrium that may be of interest.
Capitalizing on the weaker linkage disequilibrium in African Americans compared to EA populations, we were able to fine-map the SLC2A9 signal from 263 kb to 37 kb.
Additionally, our findings demonstrate the utility of following-up EA populations GWAS signals in African-ancestry populations with weaker linkage disequilibrium.
In contrast, using follow-up samples of individuals with ancestry differing from the discovery sample (specifically, populations with weaker linkage disequilibrium patterns) potentially allows for resolution of the location of the GWAS signals through the weaker linkage disequilibrium patterns in the follow-up population.
Three of the regions with suggestive linkage to AR in our study have been reported previously (2q14-q21, 2q23, and 12p13) as well as two of the regions with weaker linkage to AR (22q12-q13 and Xp21).
Of the 569 unique locations on the human genome, 19 were positioned in OMIM PARK loci and 51 within genomic regions that have a weaker linkage to PD, which are not recorded in the OMIM database and need further confirmation.
Hydrogen atoms in water molecules are attracted to regions of high electron density and can form weak linkages, called hydrogen bonds, with those regions.
Denaturation involves the breaking of many of the weak linkages, or bonds (e.g., hydrogen bonds), within a protein molecule that are responsible for the highly ordered structure of the protein in its natural (native) state.
