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Drug companies expend a lot of money and effort to ensure they get the warning labels they want on their drugs, sometimes even pushing for weaker labels in an effort to improve sales, said Robert Gordon, a lawyer with the prominent plaintiff firm of Weitz & Luxenberg in New York City.
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Positive labelling for aggrecan core protein, 6B4, was observed intensely in the outer regions of the pellet with weaker labelling demonstrated in central regions (Fig. 4K).
Labeling for neuroglian was primarily in the 25% sucrose fraction, with weaker labeling for the 30−35% interface and the 40+60% fraction (not shown).
After 8 h p.i., nuclei showed weaker labelling and a modified appearance: newly synthesized viral particles could be observed as single dots in the cytoplasm.
In contrast to the staining in the crypts, the apical region of the villi showed a weaker labeling for PLEKHA7, whereas the labeling for ZO-1 was of similar intensity throughout the villus (arrowheads in Fig. 3F-F").
In contrast, direct labeling of MBP-fGly with AO-AF488 produced weaker labeling under similar conditions.
PPR labeling was particularly intense in the neuronal nucleus (Figs. 3j l, 4j l), although weaker labeling was distinguished at the cell surface and in the cytoplasm.
As shown in Fig. 5, numerous nerve cells in spinal cord were labelled 4 h after the injection, with weaker labelling at 2 h.
Additionally, this intense labelling of esterified pectin in tricellular junctions remained up to maturation in 'Scifresh' fruit, whereas mature 'Royal Gala' fruit displayed weaker labelling.
Antibody PG5 strongly stained cortical neurons and astrocytes, with weaker labelling of neuropil threads in dentate gyrus and molecular layer of the hippocampus.
A subcutaneous depot (1 mg) produced weaker labelling, but individual cells could still be detected, whereas i.v. (1 mg) delivery produced only very faint staining.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com