If we are less certain of the magnitude of the benefits and risks, burden, and costs, and thus their relative impact, we make a weaker Grade 2 recommendation.
Because of the scarcity of UUT-UC cases, clinical practice is guided by low levels of evidence and weak grades of recommendation (i.e., C) even in the most recent international guidelines (Roupret et al, 2011).
Ask about your quality of work and reasons for any weak grades.
Addition of steroid may provide longer relief, but the evidence remains weak (Grade C recommendation).
However, due to limited data these recommendations have a weak grading.
Among all recommendations, 9 were strong (Grade 1±) and 16 were weak (Grade 2±), and for eight questions, it was impossible to apply the GRADE® method.
This resulted in 30 recommendations: 3 recommendations were strong (Grade 1), 13 were weak (Grade 2), and 14 were experts' opinions.
The grading scheme classifies recommendations as strong (grade 1) or weak (grade 2), according to the balance among benefits, risks, burdens, and possibly cost, and the degree of confidence in estimates of benefits, risks, and burdens.
The experts summarized the work and applied the GRADE® method, resulting in 30 recommendations: 3 recommendations were strong (Grade 1), 13 were weak (Grade 2), and 14 were expert opinions.
The 12 TNBC cases expressed MAS1 at "weak" grade, whereas 48 cases of the 120 non-TNBC cases expressed MAS1 at "weak" grade (P < 0.0001).
