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This mechanism is actually similar to viscous shear theory since weakening interaction between C S H particles is also the function of water lubricant.
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Further study has revealed that weakened interaction between CD44 and hyaluronan decreases the production of MCPs and consequently undermines the recruitment of mononuclear cells [21].
Therefore, a mutation at P137 could further weaken interaction between helix-1 and the rest of the C-terminal domain.
The weakened interaction between the two domains in Y279C results in an increased level of binding between the N-SH2 domain and its pTyr ligands.
Increasing the net charge causes weakened interaction between the APS2– and SAC complex and as a consequence, reduces APS channeling efficiency (Fig. 3).
As mentioned above, PtdIns(4,5 P2 disrupts yeast profilin-actin interactions (Lassing and Lindberg 1985; Goldschmidt-Clermont et al. 1991; Ostrander et al. 1995) and in other systems weakens interaction between CP and actin-filament ends (Schafer et al. 1996).
Lysine acetylation neutralizes the positive charge on histones and thus weakens interactions between histones and DNA.
In particular, contents of PANI-LSA are quite small, and therefore, quantities of the plasticizing dopant LSA are not enough to significantly weaken interactions between PS macromolecules.
We conclude that the C-terminus is not necessary for CKIε to bind to substrates (see Fig. 3), but that it stabilizes otherwise weakened interactions between xDsh or mPer1 and CKIε.
It is caused by specific mutations in gyrase and topoisomerase IV that weaken interactions between quinolones and these enzymes.
We speculate that binding of ITC metabolites to the allosteric site weaken interactions between HDAC3 and SMRT, which facilitates complex dissociation and GCN5 (HAT) recruitment on CtIP.
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