In addition, this cooperation works under hypoxia where the increased level of glycolysis compensates OXPHOS weakened function [ 14].
Negative plasticity is a term used to refer to the age-related cognitive decline and degradation in brain function that results from decreased brain use and weakened function of top-down neuromodulatory systems that underlie efficient learning and memory (Moller et al. 2006).
However, on the other hand, senescence results in in vivo aging, weakening the function and renewal of stem cells [ 10].
For the LacI family, we used the results of extensive mutational analysis of LacI from E. coli [ 21] and defined true SDPs as all positions, whose mutation resulted in a weakening the function of the protein (groups IV to XV from [ 21]).
To a certain extent, this formulation not only weakens the function of weighting functions in the control synthesis but also reduces the order of the designed controller.
Therefore, we considered that increased AS could be a result of inaccurate splicing, which could weaken the function of the corresponding genes by decreasing the functional transcripts.
These characteristics of the different analyses explain why Multiplate®-assays, COL, TRAP, ASPI and Sonoclot assays, CR and PF, in our study show strengthened platelet function and coagulation over time, and on the other hand, P2Y12-sensitive VASP analysis show weakened platelet function in ticagrelor treated patients.
The dual point mutations K130M/V131I in this region result in enhanced functionality of HBx, whereas mutations of C-terminal truncation or deletion may weaken the function of HBx in upregulating HIF-1 α.
Although no causal link has been established, the agents have been associated with atypical honeybee behaviour and weakened immune function, which may worsen preexisting pathogen infection.
