Sentence examples for weakened expression of from inspiring English sources

Multiple mechanisms appear to contribute to the decreased DIO2 activity, including weakened expression of DIO2 mRNA, competitive inhibition of DIO2, and enhanced post-translational degradation of DIO2.

By 8 days, low-dose 4OHT-treated SGs were hyperplastic, exhibiting weakened expression of FASN and increased proliferation.

The null mutant of dPob shows quite characteristic phenotype; no detectable protein expression of Rh1, and very weakened expression of other multiple-transmembrane domain proteins such as Na+K+-ATPase or TRP in the mosaic retina.

The null mutant of dPob shows a characteristic phenotype with no detectable protein expression of Rh1 and very weakened expression of other multiple-transmembrane domain proteins such as Na+K+-ATPase in the mosaic retina (see below).

Clearly, if the level of transcription of Leu1 is diminished, expression of the protein and enzymatic activity will be decreased, which was observed, though this loss of Leu1p activity was attributed previously to weakened acquisition of the iron−sulfur prosthetic group by the intact and abundant apoprotein.

Forty-four prothens, thexpressionof of which is higher in a situation of proper biofilm formation, and 13 proteins of weakened expression were identified using electrophoretic techniques [ 13].

That is, in the case of weakened enhancers, expression of the reporter gene was maintained at different levels in different clones and varied significantly among cells within individual clones.

Spindle checkpoint proteins are essential for survival in mammalian cells (10- 12), thus researchers have used either cancer cells with weakened checkpoint function or cultured cells with conditional expression of mutant checkpoint proteins or siRNA to investigate the correlation.

Moreover, a reduced inhibition of RAD52 expression of C allele, probably due to a weakened binding capacity of hsa-let-7 to 3′-UTR of RAD52, was demonstrated by luciferase activity assay in MCF-7 cell line [ 50].

This is likely secondary to weakened Ihh expression in the cartilage of the Catnbc/c; Col2a1-Cre mouse embryo [9], [14], since ligand-independent activation of Hedgehog (Hh) signaling in the Catnbc/c; Col2a1-Cre mice rescues PTHrP expression [12].

The lower expression of the Cyp19a1 in the mutant GCs suggested a weakened FSH responsiveness.