Nine other mutants showed weakened activity, from 10%to50%0% survival.
Replacement of Tyr75 for Phe in rhizopuspepsin by site-directed mutagenesis led to some, weakened activity [ 21].
Given that bone turnover is generally affected by the balance between bone resorption (mediated by osteoclasts) and bone formation (mediated by osteoblasts), it is reasonable to assume that insufficient DNA methylation activity weakens osteoblastic activity or enhances osteoclastic activity.
"The public finances look poised to take a serious hit from probable significantly weakened economic activity after the Brexit vote taking a toll on tax receipts in particular.
That, Howard Archer of IHS Global Insight says, means the European Central Bank could cut rates in the months ahead: There is nothing alarming in the December Eurozone inflation data and underlying inflationary pressures seemingly remain muted amid extended weakened economic activity and high and rising unemployment.
Transgenic mice that were engineered to have interruptions in the BRCA2-BubR1 association exhibited marked decrease of BubR1 acetylation, weakened SAC activity, and aneuploidy.
Here an association between the two repeats was also required; separating them as in LigB7'-9 and LigB10-12 significantly weakened the activity observed with intact LigB7'-12 (Figure 5B).
The R-to-W conversion in the context of PTPN22.1 further weakened NFAT activity and IL-2 production.
Consequently, weakened BGL activity leads to decreased production of glucose via cellobiose hydrolysis, resulting in an indirect release from carbon catabolite repression of cellulase expression by glucose.
Western blot results showed that Akt phosphorylation decreased sharply on Day 12 and remained low afterward (Fig. 2D), indicating quickly weakened Akt activity in culture in concomitant with the rapid senescent process.
