Sentence examples for weaken its interaction from inspiring English sources

The core sequence of DBE is TGTT, and a single base-pair replacement in this sequence might significantly weaken its interaction with forkhead proteins.

Mutations in the AID that weaken its interaction with β subunits may allow a new orientation, which explains why the W391A mutation in α12.2 abolishes β1 but not β2a regulation [30].

Our simulations suggest that reduced calcium sensitivity results from an inability of mutant Tn to weaken its interaction with actin independently of calcium binding to wild-type Tn (Fig. 4).

Additionally, in the case of (Sp -cGMPS, replacing the equatorial oxygen with Sp -cGMPSuld weaken its intereplacingitheArg316 and Thr317 without affequatorial interactioxygenh Ala309.

It associates with the Smc1 head and weakens its interaction with Smc3 (Rao et al, 2001; Weitzer et al, 2003).

Interestingly, however, while our previous observations indicated that the wild-type nonphosphorylated PAGE4 protein interacted with c-Jun, here we show that phosphorylation of PAGE4 weakens its interaction with c-Jun in vitro.

Furthermore, modification of HDAC1 by small ubiquitin-like modifier (SUMO) in vitro weakens its interaction with CoREST whereas sumoylation of HDAC1 stimulates its binding to ZNF198.

Altogether, these results argue that phosphorylation of serine 62 in Bcl-xL weakens its interaction with Bax and enhances its sensitivity to pharmacological inhibition.

Acetylation neutralizes the positive charge of lysine resides and weakens its interaction with negatively charged DNA, thereby conferring a more open chromatin structure and allowing active transcription.

They suggested that the five differences of residues in the ED3 domains of YFV(17D) could attenuate the virus by weakening its interaction with RPSA.

On the other hand, in the cytosol of BCLAF1-knockdown cells, Ku70 enhanced its binding to Bax but weakened its interaction with p18-cyclin E, suggesting that BCLAF1 is required to release Bax from the anti-apoptotic Ku70 Bax complex in high-dose-irradiated IR-responsive cells.