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In particular, contents of PANI-LSA are quite small, and therefore, quantities of the plasticizing dopant LSA are not enough to significantly weaken interactions between PS macromolecules.
It is caused by specific mutations in gyrase and topoisomerase IV that weaken interactions between quinolones and these enzymes.
It thus appears that the mutation may weaken interactions with ubiquitin required for substrate recognition and/or catalysis.
We speculate that binding of ITC metabolites to the allosteric site weaken interactions between HDAC3 and SMRT, which facilitates complex dissociation and GCN5 (HAT) recruitment on CtIP.
In contrast, inhibitors that stabilize helix αC in an active conformation weaken interactions between the SH2/SH3 domains and their respective intramolecular ligands.
Intriguingly, the phosphoinositide PtdIns(4,5 P2 (which is critical for endocytosis; see Vesicle Scission and Uncoating) can weaken interactions between CP and barbed ends in other systems (Schafer et al. 1996).
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Therefore, a mutation at P137 could further weaken interaction between helix-1 and the rest of the C-terminal domain.
To engineer controlled degradation, we have designed a series of modified ssrA tags that have weakened interactions with ClpXP.
These weakened interactions led to a lowering of the Cu particle embedment, coinciding with a pronounced Cu crystallite growth during reduction.
The CA-NC tubular complexes that are formed with mutations in CA that help HIV-1 escape from Mx2 restriction exhibit weakened interactions with Mx2 (Fricke et al., 2014).
In this case, mIn this utation in the fifth codon of sORF 1 (U75A) may also affect splicing by weakening interactions with the U1 and U6 snRNAs [35].
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